Sentence examples for mutation requires further from inspiring English sources

The possibility of a protective effect of a therapeutic (and possibly spontaneous) abortion among women with a BRCA2 mutation requires further investigation.

However, the relevance of these additional mutations requires further investigation.

The clinical implication for these mutations requires further validation.

The efficacy of targeted drugs on patients with the related oncogenic mutations requires further validation.

While a true frequency of these mutations requires further testing in a much larger cohort, these data suggest frequency is unlikely to be high and should parallel the range (0.7 to 5%) that is observed in female breast cancer.

How presynaptic defects and abnormal DA homeostasis lead to neuronal cell death associated with LRRK2 mutations require further investigations.

The complex pathophysiology and the role of the neural crest, venous dysplasia, and novel mutations require further clarification.

The presence of truncated proteins in cells from mutation carriers requires further experimental validation.

Of course, whether adaptive and/or reverse mutations are selected requires further analysis of quasispecies during the course of persistent infection.

In contrast to the findings of Alegre-Abarrategui et al., however, these autophagy-lysosomal defects were not observed in the R1441C knock in mouse model and hence the impact of LRRK2 PD related mutations on ALP requires further investigation [76].

The clinical data therefore suggest that myeloma is not purely due to mutations resulting in increased paraprotein levels but also requires further mutations to transform the plasma cells to a cancerous state.