Sentence examples for mutation requires a from inspiring English sources

Moreover, the Ile219->Lys mutation requires a single nucleotide change, which also increases the probability of such a mutation to occur.

For example, subtype C viruses are significantly more likely than subtype B viruses to develop the non-nucleoside RT-inhibitor-resistance mutation V106M because this mutation requires a single substitution for subtype C viruses (GTG→ATG) but two substitutions for subtype B viruses (GTA→ATG) [15], [16].

Unraveling the pathophysiology of the condition most likely resulting from the SLC2A2 mutation requires a thorough understanding of the function of GLUT2, the protein encoded by SLC2A2.

It should be noted that RIP mutation requires a minimum repeat length and we would not expect it to occur in repeats less than 400 bp in length [ 20, 21].

Minimizing somatic mutation requires a second group of genes (the 'caretakers'; Kinzler and Vogelstein 1997) and involves error-free DNA replication, effective DNA repair, and the maintenance of appropriate epigenetic patterning (Sarkies and Sale 2012) and chromosomal structure (Stoler et al. 1999).

Those with one mutation, or an initial IRT >99.9 percentile and no detected mutation, require a second bloodspot test to verify if IRT is still elevated at 3 4 weeks when IRT levels are more discriminatory.

Only patient number 6, presenting a MWS/CINCA phenotype with a T348M mutation, required a higher dose (3.7 mg/kg) due to persistent elevation of acute phase reactants (Table 2).

To study such extremely rare mutations requires "a very large denominator," or huge numbers of subjects, Roden says.

First, an excess of non-synonymous mutations requires a long time to accumulate [ 47].

In practice, any test that identifies driver genes by recurrent mutations requires a good estimate of the passenger mutation probability q.

However, microarrays for diagnosis of disease-causing genetic mutations require a 100% assay success rate, suggesting that an alternative strategy for assay development is required.