Sentence examples for mutation remains unknown from inspiring English sources

Genetic analyses have identified a homozygous Trak1 mutation resulting in a C-terminal truncated form of Trak1 as the cause of recessively inherited hypertonia (Gilbert et al., 2006), but the pathogenic mechanism of Trak1 mutation remains unknown.

Whereas the precise mechanism of the effects of each individual HAT or replication factor mutation remains unknown, it is apparent that core X- and Y' moderate all these effects.

One virus that harboured heterozygote coding mutations, including PB2 D567D/G, was attributed to a severe and potentially mixed infection; yet the functional significance of this PB2 mutation remains unknown.

While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease.

The structural and functional basis of several XLA-causing mutations remains unknown, since only the structures of the PH and SH3 domains of human Btk are currently available.

The impact of other minor KRAS mutations remains unknown.

Although frequent mutations of SPOP in endometrial cancer have been identified, the functional impact of these mutations remains unknown.

Yet whether this divergence is due to inadvertent selection in the lab or the fixation of deleterious mutations remains unknown.

However, other PD-linked parkin mutations have no discernible impact on the intrinsic ubiquitin ligase activity, solubility or other biochemical properties of parkin (Hampe et al., 2006), and the pathogenic mechanism of these mutations remains unknown.

Thus, whether imatinib could be used in NPC patients with KIT mutations remains unknown, and further clinical trials are necessary to validate the efficacy of imatinib for treating NPC patients with KIT mutations.

In most other cases of CSS, however, the proportion of inherited susceptibility versus de novo mutations remains unknown.> -wrap-foot> *And cell cycle regulation With the ongoing efforts to personalize cancer medicine, comprehensive genome analyses will increasingly find its way into daily clinical routine in pediatric oncology.