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The synonymous mutation relationships are shown in Figure 3B.

The predicted protective efficacy up to 12 months shows a decrease for all frequencies of the dhps double mutation (Figure 5), although again the relationship is uncertain for higher dhps double frequencies, and as noted the relationship for the 12 month outcome may be biased due to variations in study design.

93 The best-characterized synthetic lethality relationship is between BRCA mutation and PARP1 inhibition.

A key feature of the EMU, Mutator and LEAP-FS systems is that they exploit known sequence information about genes to validate identified gene or protein mutation relationships; in (7, 10), this external knowledge is applied as a filter after a putative gene mutation relationship is identified while in (30), it is used to build reliable training data for inferring linguistic relational patterns.

The well-established negative association between BMI and educational status was not found in MC4R loss-of function mutation carriers, although a significant relationship was seen in MC4R non-mutation carriers of the corresponding pedigrees [ 110].

Patients with chronic lymphocytic leukemia harboring a homozygous C allele displayed inferior clinical outcome irrespective of immunoglobulin heavy-chain variable (IGHV) gene mutation status, whereas no similar relationship was observed in patients with acute myeloid leukemia (AML).

No relationship was confirmed in mutations with severe AP: mild AP mutation of CFTR in 4 (2.8 %) patients, and in the SAP mutation of CFTR in 1 (2.6 %) patient.

Building conclusions about network topology by drawing links between genes whose causal relationship was discovered by mutation experiments can lead to incomplete and sometimes even incorrect connections.

No significant relationship was found between MGMT methylation and the mutations (Table 3).

Swap mutation, arithmetic mutation, jump mutation, uniform mutation and creep mutation are some of the well-known mutation operators.

Following the identification of de novo mutations in TUBB5, parental relationships were confirmed using a suite of microsatellite markers.

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