Sentence examples for mutation reduces the from inspiring English sources

The process of mutation reduces the chance of trapping in local optima [12].

Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT).

In particular, we consider a scenario of purifying or negative selection in which all mutations are deleterious and each new mutation reduces the fitness of the individual by the same fraction.

In a dose response study, we found that introduction of an ΔrpoS mutation reduces the protective efficacy of a live S. Typhimurium strain (unpublished results).

Mechanistically, this is explained by the fact that the R621C mutation reduces the lipofilicity of synphilin-1, because it is in the middle of the sequence required for phospholipid and membrane binding [42].

While we do not explicitly consider the role of the module that contains the synergy site, we note that a R1445A mutation reduces the affinity of FN fragments, which contain the synergy site (7 10FNIII), to cell-surface receptors [25].

If the mutation reduced the number of eggs produced by that mosquito, the population could be wiped out, along with any malaria parasites it carried.

According to the docking simulation in GOLD, the T315I mutation reduced the binding affinities of imatinib, dasatinib, nilotinib, and bosutinib by 59, 46, 47, and 30%, respectively (Fig. 5a, Additional file 1: Table S6).

The E406A mutation reduced the apparent affinity and the catalytic activity of cGMP by only 2-fold (Table 2).

Interestingly the R102Q mutation reduced the α-helical propensity of surrounding sequence by approximately four-fold (Table S1).

This missense mutation reduced the acetyltransferase activity of ESCO2 in vitro, which suggests that it is actually pathogenic.