Sentence examples for mutation reduced the from inspiring English sources

In their original simulation, each deleterious passenger mutation reduced the cell's fitness by about 0.1percentt.

If the mutation reduced the number of eggs produced by that mosquito, the population could be wiped out, along with any malaria parasites it carried.

In the context of this model, the simplest explanation is that the absence of helix D or its disruption by the L609R mutation reduced the stability of AB-CaM* in the trans-binding mode.

According to the docking simulation in GOLD, the T315I mutation reduced the binding affinities of imatinib, dasatinib, nilotinib, and bosutinib by 59, 46, 47, and 30%, respectively (Fig. 5a, Additional file 1: Table S6).

Interestingly the R102Q mutation reduced the α-helical propensity of surrounding sequence by approximately four-fold (Table S1).

This missense mutation reduced the acetyltransferase activity of ESCO2 in vitro, which suggests that it is actually pathogenic.

The G118V mutation reduces the flexibility and increases the hydrophobicity of the polypeptide chain.

A high tolerance mutation reduces the killing rate of the whole population.

Wang et al. confirmed, however, that N51A mutation reduces the in vitro deaminase activity of AID on C down to background.

The R105Q mutation reduces the hORC1BAH-DNA binding affinity, leading to impaired hORC1BAH-nucleosome interaction, which likely influences DNA replication initiation and MGS pathogenesis.

Another interesting observation relates to the F89 residue: in the case of quinine binding, the mutation F89A seems even more favorable compared to the wild-type receptor, while in other complexes this mutation reduces the agonist activity.