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Some of the side chains whose mutation reduce DNA binding form clusters on a surface near the amino terminus.
(B ) Mutations in the C-terminus of Drosophila Orc6, including the MGS mutation, reduce the affinity of Orc6 for Orc3.
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We found that STIM1 interacted with WT UNC93B1 but 3d mutation reduced this interaction (Fig. 4a).
The G118V mutation reduces the flexibility and increases the hydrophobicity of the polypeptide chain.
A high tolerance mutation reduces the killing rate of the whole population.
In their original simulation, each deleterious passenger mutation reduced the cell's fitness by about 0.1percentt.
The Afh mutation reduces circadian oscillations at the single cell level outside the SCN, resulting in alterations of metabolism22.
Smith, D. et al. A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
If the mutation reduced the number of eggs produced by that mosquito, the population could be wiped out, along with any malaria parasites it carried.
Wang et al. confirmed, however, that N51A mutation reduces the in vitro deaminase activity of AID on C down to background.
The R105Q mutation reduces the hORC1BAH-DNA binding affinity, leading to impaired hORC1BAH-nucleosome interaction, which likely influences DNA replication initiation and MGS pathogenesis.
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