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The matching of genotype (of the baby) with phenotype (of the living adult) was possible because the mutation ratio of individuals in this family were known.
These mutants have been identified by 246,566 flanking sequence tags (FSTs) and cover 65%% (25,275 of 38,869) of the non-TE genes in rice, while the mutation ratio of TE genes is 25.7%%.
This compound has been observed to induce a mutation ratio of 20.4, suggesting that quercetin contributes to the mutagenic potential of this genus.
Nonsynonymous nucleotide substitutions detected in these analyses (with thresholds for total coverage of ≥30× and for the mutation ratio of ≥20%) included 56 alterations in 53 independent genes (Table S2).
Mutation ratio of m.5541C > T in the patient was determined as follows: Extracted DNA (1 ng) was used as template for quantitative PCR with TaqMan Universal PCR Master Mix kit (Applied Biosystems) according to the manufacturer's instructions.
Although genetic characterization of tumor tissues demonstrates that mutation of the p53 gene is the most common genetic alteration in human cancers, the mutation ratio of the p53 gene in uterine cervical cancer is relatively low [ 4, 5].
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Mutation ratios of the 186 clades were sorted by coalescence ages of the clades and averaged over a "time-window" of 15 clades with similar coalescence ages in a sliding window analysis.
Rates of recombination, estimated with 12 new loci using ClonalFrame [30], are close to previous reports [28] using five loci with a recombination to mutation ratio (r/m) of 3.8.
The recombination to mutation ratio is indicative of the contribution of recombination relative to mutation in generating allelic diversity [ 39] which can be measured by Nei's diversity index [ 42].
In the samples with co-occurring mutations, the ratios of KRAS mutation ratio (KRAS mutation peak area/total peak area) to the PIK3CA mutation ratio (PIK3CA mutation peak area/total peak area) was determined.
This single account is important because it reveals how biomedical information and the diagnostic criteria of mutation ratio, can be interpreted.
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