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Exact(30)
Relative increases in mutation rates with respect to the control strain (ΔnucS/nucSTB; set to 1) are shown inside the column.
The top three highest mutation rates with relative larger total sample size for LATS1 occurred in stomach adenocarcinoma (5.91%, n = 220), uterine corpus endometrial carcinoma (4%, n = 248), and bladder urothelial carcinoma (3.1%, n = 130).
However, if selfing facilitates efficient purging, then selfing organisms may be capable of absorbing increased mutation rates with few fitness consequences.
The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population.
Both polA6 and polA1 cells have increased mutation rates with respect to their isogenic Pol+ strain (7.3±2.1-fold 7.3±2.1-foldfold respectively, Tande 1), and their rates do not differ from each other (Figure 1D; Table 1).
The dS values (Table 1) indicate that CatSper and CatSerβ genes contain high mutation rates, with an ∼2-fold increase over those of housekeeping genes, other tissue-specific genes and sperm-specific genes.
Similar(30)
We believe this recurrence to be the consequence of a high mtDNA mutation rate with restricted mutational signature (CH > TH and TL > CL).
Vogelstein and Tomasetti recently suggested cancer risk scales sub-linearly with the normal rate of stem cell divisions in the tissue of origin, suggesting a key role for DNA replication in mutation processes, and multiple 'mechanogenomics' mechanisms might explain the additional scaling of mutation rate with tissue stiffness.
Clear cell renal cell carcinoma (ccRCC), the most common form of renal cell carcinoma, is characterized by a relatively low mutation rate with few mutations shared among patients.
In this paper, four genetic algorithm parameters are investigated, namely, population size, number of best timetables that are copied over to the next generation, crossover rate, and mutation rate with rang values shown in Table 2.
He found that trait heritability was a function of an interaction between the average number of inputs per gene and mutation rate, with maximum heritabilities at intermediate mutation rates.
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