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Since microsatellite markers and the D-loop sequence of mitochondrial DNA have a high mutation rates, they provide information about recent evolutionary history as compared to slow mutating genes that provide data about ancient history [ 21].
Applying a statistical method for analyzing mutation rates, they showed that the gene accumulated mutations in males as much as 6.5 times faster than in females.
Apart from high mutation rates, they influence a variety of phenotypic traits from skeletal morphology to host-pathogen interactions [ 13, 14].
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Because AFLPs exhibit a relatively high mutation rate, they may be informative for both historical and contemporary processes.
In addition to mononucleotide repeats, tetranucleotide repeats, and to some extent also dinucleotide repeats, are other important determinants of the local mutation rate; they are also involved in phase variation in a number of pathogenic bacteria [ 35].
Using cumulative skew diagrams, I found that mutational patterns in the SARS-CoV genome were strikingly different from other coronaviruses in terms of mutation rates, although they were in general agreement with the model of the coronavirus lifecycle.
McGowen and colleagues thought this would mean the dolphin's genome would have rapid mutation rates, but they found the opposite.
Taken together, these bacteria may experience elevated mutation rates because they lack a functional MMR system.
Transcriptionally active genes experience higher mutation rates, but they also exhibit higher rates of DNA repair (Boulikas 1992).
Above, we have seen that random units of replication are not viable at high mutation rates; hence, they cannot be competitors of the master sequence.
RNA viruses generally have very high mutation rates as they use polymerases which cannot find and fix mistakes, and are therefore unable to conduct genomic repair of damaged genetic material.
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