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Our study raises the potential importance of haploid phase selection and high deleterious mutation rates on mutator success in sexually reproducing populations.
Redfield [ 19] modelled the effect of elevated male mutation rates on the mutational load in infinite sexual populations and compared the results with those from infinite diploid asexual populations.
Together, these results demonstrate that Cas9 does not elevate mutation rates on the genome-wide scale or compromise genome integrity.
We present a model to study the effect of phenotypic mutation rates on the amount of abnormal proteins in a cell.
Both diseases showed overall low somatic mutation rates (on average 4.6 mutations per exome); mutations identified in pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma were seen in pathways important for transcription, intracellular signaling and cellular organization.
We used the jModelTest program59 to select the best-fitting substitution model for our sequences according to the Bayesian information criterion, and the date of isolation of each isolate was used to calibrate the tree, and finally these analyses were performed using a log-normal relaxed molecular clock, which allows for different mutation rates on different branches.
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(b) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).
(c) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).
(d) Region with increased maternal mutation rate on chromosome 2 (chr2: 0-10,000,000).
Then, a novel general effect of mutation rate on minimized objective value are presented.
Here, we model the influence of varying phage mutation rate on the efficacy of phage therapy.
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