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Mutational variances are affected by mutation rates of individual traits and the sensitivity of the traits to mutations (genetic potential).
Although this work has provided insights into the mutational dynamics of highly mutable STRs, the mutation rates of most others remain unknown.
Mutation rates of the wild-type and mutator strains to kanamycin resistance and phage resistance.
(d) Mutation rates of off-target sites of gRNA2.
Schug, M. D., Mackay, T. F. C. & Aquadro, C. F. Low mutation rates of microsatellite loci in Drosophila melanogaster.
The mutation rates of ssDNA viruses are extremely high and approach those of viruses with RNA genomes4.
The major problem with creating an Aids vaccine is that due to the high mutation rates of the virus there are many strains.
Previous studies have estimated the mutation rates of highly polymorphic STRs by using capillary electrophoresis and pedigree-based designs.
Notably, the mutation rates of 104 (2.5%) CNVRs were estimated at the order of 10−3 per generation; therefore, they were identified as potential hotspots.
Combining the gene-specific mutation rates of all individual mTOR-related genes, we found a significant enrichment for de novo mutations in mTOR-related genes (p = 3.50e−04) (Supplementary Table 1).
In cells from a patient with an XRCC1−/− mutation, rates of break repair are reduced and the single-strand break sensor protein PARP1 is hyperactivated, resulting in abnormally high levels of cellular ADP-ribose.
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