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To compensate for this near-doubling of mutational target size given network genetic architecture, I doubled the mutation rates from 0.001, 0.0001, and 0.00001 to 0.002, 0.0002, and 0.00002 in the linear genotype simulations.
Next, we developed MUTEA, an algorithm that infers STR mutation rates from population-scale data by using a high-resolution SNP-based phylogeny.
Matthew Hurles and colleagues report the first direct comparative analysis of male and female germline mutation rates from whole-genome sequences of two parent-offspring trios sequenced as part of the 1000 Genomes Project.
We observed a slow adaptation of C. trachomatis to the in vitro environment, which was essentially governed by four mutations for L2/434/Bu and solely one mutation for E/CS88, corresponding to estimated mutation rates from 3.84 × 10−10 to 1.10 × 10−9 mutations per base pair per generation.
Our estimates are consistent with experimentally determined mutation rates from other studies.
The origins of limits on mutation rates from above are perhaps harder to untangle.
Similar(21)
The mutation rate from the normal allele to the achondroplasia allele is about 5 × 10−5.
If 5mC occurs predominantly in CpG pairs, the above-mentioned mechanism will increase the mutation rate from CpG to TpG or CpA and induce an underrepresentation of CpG29.
Despite the existence of a specific repair mechanism that restores G/C mismatch, the mutation rate from 5mC to T is therefore 10-fold to 50-fold higher than other transitions, depending on local GC content27.
In genetic algorithm, we have used crossover rate from 0.1 to 0.9 and mutation rate from 0.01 to 0.09 with and without elitism.
This is highly intuitive: the greater the mutation rate from A1 to A2, the greater the frequency of A2 that can be maintained at equilibrium, for a given value of s.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com