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We note that the mutation rates considered here may differ from the actual mutation rate in Stegodyphus species and that these time estimates should be considered with caution.
Indeed, regarding the recombination model, equations similar to (4) and (5) can be derived for transversion rates (33) (34) where and are the mutation rates, considered as constant, corresponding to the transversions from A T to C G and from C G to A T, respectively.
Similar(58)
Compared to the real world, the mutation rate considered in the game is very high, as arbitrarily set by the previous design of the roulettes.
Low and high diversity loci may simply indicate a lower or higher mutation rate at these loci than the average mutation rate considered over all loci (see Methods).
In our system, the population that performs worst under a new selective pressure at any of the values of μ2 assayed is that one previously optimized at the lowest mutation rate considered (μ1 = 0.001; see Fig. 3).
In this case and with the value of the mutation rate considered, the levels of within host genetic variability can be very low.
The parameters of each model (i.e. population sizes, timings of demographic events, mutation rates) were considered as random variables drawn from prior distributions (see Additional file 8).
Mutation rates are considered to be constant or externally regulated.
Two different mutation rates were considered: 10−10 and 10−9 mutations per site per year.
Differences in mutation rates were considered significant when P ≤ 0.05.
Even when conservative mutation rates are considered, unused genes would be expected to have accumulated mutations.
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