Sentence examples for mutation rates by from inspiring English sources

As a result of natural selection, entry into error catastrophe does not imply the "breakdown of evolutionary adaptation" but, on the contrary, the adaptation to higher mutation rates by increasing the mutational robustness of the population.

Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts.

Some have shown that extending the guide RNA by two nucleotides reduces off-target effects, while in Joung's hands truncatingthe guide RNA reduces off-target mutation rates by up to 5,000 fold.

Third, we excluded the possibilities that Pol I or Pol III altered Pol IV-dependent mutation rates by proofreading and correcting Pol IV-generated errors (Figure 1D,H, Table 1).

Metabolic rate and generation time (both correlated with body size) may affect mutation rates by altering the mean residence times of nucleotides, such that these would tend to be shorter in small, short-lived and metabolically active species [16].

We were able to use a male-lethal mutation (xol-1; [28]) to enforce obligate self fertilization on C. elegans populations and elevated mutation rates by treating populations with ethyl methanesulfonate (EMS).

RNA viruses can escape the negative consequences of the increase of the mutation rate by selecting anti-mutator mutants [34].

Disruption of the proofreading activity by site-directed mutagenesis significantly increased a mutation rate by as much as 10-fold to >100-fold, and the mutator effect is particularly strong in DNA polymerase δ.

Individual genes/proteins can decrease their phenotypic mutation rate by using preferred codons or by increasing their robustness against amino acid substitutions.

We have also investigated the role of crossover rate and mutation rate by taking different values.

"It's excellent that they have been able to get a better baseline for calibrating the mtDNA mutation rate by looking at ancient DNA".