Evolutionary stress can drive selection for increased mutation rates: mutator bacterial strains are more antibiotic resistant than non-mutator strains, and thus have a clear selective advantage, potentially leading to an increase in the overall mutation rate within a population [13].
However, since it is generally believed that on average the effective population size is constant for all the loci in a specific sample, our comparisons of population mutation rate within samples/species should be valid.
The effective population size was assessed assuming a mean mutation rate within a range of 4.5*10−5 to 15*10−5 per generation.
This reduced p53 bcl-2 ratio (indicative of loss of both cell-cycle control and regulation of the major apoptotic pathway) acts to increase mutation rates within a clonal cell population, aiding tumourigenesis and expansion of solid malignancies.
One that came up a bunch yesterday is the population mutation rate or the population scale mutation rate 4Nmu.
The distribution of pairwise genetic distances between samples taken from epidemiologically linked carriers depends on numerous factors, such as the mutation rate, the within-host pathogen population dynamics, and the transmission bottleneck size.
If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely that mutation rate and population size are indpendent, because population expansion would increase heterozygosity that in turn would increase mutation rate.
The parameters used in the GA include the crossover rate, mutation rate, and population size.
Besides selective forces, mutation rate and population size also affect the fixation of a mutation.
We define Θ = 2 N1 UA as the population-scale mutation rate during the large population phases.
The commission wanted thousands of Yanomami blood samples to determine genetic mutation rates in a population completely uncontaminated by radiation.
