Sentence examples for mutation rate with from inspiring English sources

We believe this recurrence to be the consequence of a high mtDNA mutation rate with restricted mutational signature (CH > TH and TL > CL).

An important caveat to this is that if the mutation load increases with mutation rate, with an associated increase in genetic drift during bottleneck transmission, a mutator strategy would carry a profound cost, both for individual populations and descendant lineages in separate hosts [ 48].

Vogelstein and Tomasetti recently suggested cancer risk scales sub-linearly with the normal rate of stem cell divisions in the tissue of origin, suggesting a key role for DNA replication in mutation processes, and multiple 'mechanogenomics' mechanisms might explain the additional scaling of mutation rate with tissue stiffness.

Clear cell renal cell carcinoma (ccRCC), the most common form of renal cell carcinoma, is characterized by a relatively low mutation rate with few mutations shared among patients.

In this paper, four genetic algorithm parameters are investigated, namely, population size, number of best timetables that are copied over to the next generation, crossover rate, and mutation rate with rang values shown in Table 2.

When mutation probability increases in a non-linear fashion with respect to male age, Crow [26] found that an exponential function with a cubic term best describes the increase in mutation rate with male age in humans.

Relative increases in mutation rates with respect to the control strain (ΔnucS/nucSTB; set to 1) are shown inside the column.

The top three highest mutation rates with relative larger total sample size for LATS1 occurred in stomach adenocarcinoma (5.91%, n = 220), uterine corpus endometrial carcinoma (4%, n = 248), and bladder urothelial carcinoma (3.1%, n = 130).

However, if selfing facilitates efficient purging, then selfing organisms may be capable of absorbing increased mutation rates with few fitness consequences.

Both polA6 and polA1 cells have increased mutation rates with respect to their isogenic Pol+ strain (7.3±2.1-fold 7.3±2.1-foldfold respectively, Tande 1), and their rates do not differ from each other (Figure 1D; Table 1).

Nevertheless, it is apparent that considerable disparities can result between long-term substitution rates and instantaneous mutation rates, with direct and indirect estimates of the latter frequently yielding high values [26] [28].