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Microorganisms increase their mutation rate when stressed, perhaps addressing the growing need for evolutionary innovation.
Microsatellites interrupted by even a single point mutation exhibit a twofold decrease in their mutation rate when compared to pure AC repeats.
Indeed, deletion of UBC13 causes a 25-fold increase in the spontaneous mutation rate; when these ubc13 mutant cells were transformed with a plasmid containing OsUbc13, the spontaneous mutation rate was reduced to about fivefold (Table 1).
Mag expression, however, caused a dramatic increase in frame shift mutation rate when compared to the Apn1-deficient strain.
Specifically, it was shown that Mag expression in yeast produces up to a 300-fold increase in the spontaneous base substitution mutation rate when Mag levels are high relative to Apn1 [12].
Thus, we conclude that, while we find no strong evidence to suggest that metabolic rate and mutation rate (when measured as the root to tip path length) are correlated directly, there is an indirect relationship between these two variables, such that lineages with related mtDNA also have similar metabolic rates.
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One issue is that prostate cancer has relatively low mutation rates when compared to other types of cancer [5, 6].
Also, it is important to understand how context affects mutation rates when working in the field of molecular phylogenetics.
That is, the gene response is an indicator of regions of high chromosomal structure, and these regions result in high mutation rates when encountered by the replicating polymerases.
Cs squeezed between a 5' T and a 3' A have the lowest mutation rates when compared with any other possible immediate C-neighbourhood [ 72].
In order to check the generality of the results for different mutation rates when creating the base population, some additional scenarios were run assuming a lower mutation rate (2.5 × 10-5).
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