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There is evidence that the mutation rate varies between sites within the protein coding complement of the mitochondrial genome [18], but the degree to which the mutation rate varies is as yet unknown.
It is already known that the mutation rate varies among chromosomes.
Within a genome, the mutation rate varies greatly across genes (Gaut et al. 2011).
Two earlier experiments showed that mutation rate varies across the genome for ochre suppressor mutations and frameshifts at microsatellite repeats.
Rates can also vary if the underlying mutation rate varies [ 10, 11] or if DNA repair is impaired [ 12, 13].
Of course, in each regime the population distribution of each quasispecies changes as the mutation rate varies.
Similar(40)
The estimates of the spontaneous mutation rate vary from 10−5 to 10−9 per nucleotide per cell cycle, depending upon the experimental system used [1]; much higher rates obtain in case of cells with genetic instability [2], [3] either because of deficient DNA repair [4], or chromosomal instability [5].
When expanding the intuition from our single-locus model to whole genomes, we must bear in mind that the effective Θ determining the probability of soft sweeps is not the same for different loci across the genome because mutational target sizes and thus adaptive mutation rates vary at different loci.
Crossover and mutation probabilities and mutation rates vary for different problems, and even for different stages of the genetic process in a problem (LIN et al. 2003).
Mutation rates vary widely among different species of bacteria and even among different clones of a single species of bacteria.
Mutation rates vary among chromosomes [39] and the human-chimpanzee genetic divergence shows variation between autosomes [40].
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