In this way, elevated mutation rate paired with robustness may provide a better strategy than mutators, for high mutation rate to promote evolvability.
Compared with the wild-type bacteria, the mutator had a approximately 10-fold higher mutation rate to kanamycin resistance (approximately 10−6 per cell per generation) and a approximately 10-fold higher mutation rate to phage resistance (approximately 10−3; Data S1 and Figure S1).
Thus, this study estimated the new mutation rate to be at least 8%.
Instead, it seems likely that the bulk of genetic variance underlying diseases is due to loci where susceptibility mutations are mildly deleterious and where there is a high overall mutation rate to the susceptible class.
By sequencing up to every new cancer patient in the United States, totalling ∼1.3 million new cases annually41, we found that the minimum detectable mutation frequency is indeed expected to decrease, from the present ∼3.4 times the background mutation rate to ∼1.1 (melanoma) to 2.0 (AML) times the background (Fig. 4a).
In our case we have kept the mutation rate to be very low as the approach is capable of dealing with the low convergence rate problem by itself.
Then they counted the number of mtDNA differences between individuals and used the modern human mutation rate to estimate how long it might have taken those mutations to appear.
We estimated the average mutation rate to one mutation every 574 kb (Table 1).
Next, Clune et al. allowed various digital organisms, with various values of the mutation rate, to compete against each other.
We used the mean heterozygoty calculated of genotyped loci and fixed the mutation rate to 10−3.
Recent interest has focused on the contribution of nucleotide mutation rate to the rate of molecular evolution.
