Sentence examples for mutation rate therefore from inspiring English sources

The net mutation rate therefore represents a balance between the error-prone DNA replication process and the highly efficient error-repair mechanisms.

Most comprehensive studies of the human mitochondrial molecule have been carried out through restriction-fragment length polymorphism analysis6, providing data that are ill suited to estimations of mutation rate and therefore the timing of evolutionary events.

As Ks is lower in NMR than in mouse, the mutation rate is, therefore, also lower in NMR.

In our study, the background spontaneous mutation rate was therefore increased to detectable levels by using a strain harbouring the corresponding mutation in polymerase delta, Cdc6 cdc6-L591MM) [25].

Because the mutation rate, and therefore the rate of neutral evolution, varies across the genome, we examined closely linked ARs and focal loci.

The mutation rate may therefore have been less of a constraint on domestication than the ability of early farmers to detect and fix favourable phenotypes.

Incidentally, the high mutation rate (and therefore versatility) of cancer cells may explain why it has been so hard to find a drug that kills all the cells in a patient's cancer.

Knowledge of mutation rates is therefore an important component of a quantitative evolutionary theory (Lynch 2010).

We then assume that these substitution rates are equal to mutation rates and therefore interpret these results as the influence of mutation on substitution patterns.

Cancer genomes with unusually high mutation rates (and therefore more passenger mutations) were excluded from the analysis (see Methods section for details).

Consequently, selection detection methods that average over entire coding regions can be misleading when selective pressures differ substantially across codons; They are unlikely to find elevated nonsynonymous mutation rates and, therefore, have low power to detect signatures of positive selection (e.g. [ 72, 73]).