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In some implementations, each individual has its own mutation rate, so the adaptation of the mutation rate is performed at the individual level.
VNTRs have a relatively high mutation rate, so that they may contribute to a substantially greater degree of genetic variation than point mutation changes, or indels in general.
We approximate the Muller's ratchet by decreasing the mutation rate so that a mutation in the model corresponds to many mutations in real genomes.
The authors should point out that even if composition is controlled for, nucleotide context could have large effects on mutation rate, so the current results should be interpreted with some caution.
An important caveat of this analysis is the assumption of a slow mutation rate, so that the time for fixation (or elimination) is short relative to the length of evolutionary time between mutations.
L ¯ is independent of the total mutation rate, so if the mutation rate U is linear with time of exposure, the plot of log(V) will decline linearly with time, as commonly reported.
Similar(52)
Both measles and influenza are RNA viruses with high mutation rates, so the mutation rate alone cannot explain the differences in antigenic variability.
Proteins evolving in nature typically experience very low mutation rates, so [ 22] probably offers the best description of natural protein evolution.
Some tumors, such as the ovarian, have low mutation rates so that even with whole-genome sequencing many regions will have few mutations or not enough to confidently distinguish between events.
In addition, there are many other species traits that can influence mutation rates, so if these traits differ consistently between parasites and their nonparasitic relatives, it could potentially explain the pattern in rates of molecular evolution.
There is no significant difference in the first dS interval, most likely because of residual polymorphism and/or a low mutation rate in SO and UP clusters.
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