Sentence examples for mutation rate resulting from inspiring English sources
At mutation selection equilibrium, the increase in the mean genome-wide deleterious mutation rate resulting from the recurrent production of the mutator allele is Δ U − = Δ U p ∼ Mm.
The basis for the threat caused by this virus is the high speed of replication, short incubation time, high contagiousness, and high mutation rate resulting in constant antigenic changes.
3) Also, the mutation rate resulting from the mutagenic PCR is unknown.
The longer burn-in times and sampling periods used for slowly mutating populations are usually extended pro rata from faster simulations, with a ten-fold decrease in mutation rate resulting in a 10-fold increase in the length of the simulation.
Of interest, the partial correlation between gene body methylation level and dS disappears or even becomes positive after the control (table 2), suggesting that highly methylated regions are subject to strong selective pressure at the protein level despite the enhanced mutation rate (resulting in elevated dS) in gene bodies.
This increased mutation rate resulted from an increased frequency of terminal deletions.
The WNV genome is subject to high mutation rates resulting from high error rates and the lack of proofreading ability of the RNA-dependent RNA polymerase [ 13].
This is typically attributed to different levels of purifying selection or different mutation rates resulting from different frequencies of transcription [ 24, 37- 39].
The high mutation rates, resulting from reverse-transcriptase (RT) lack of proofreading activity coupled with a rapid replication rate and recombination, ensure that a number of highly related but nonidentical variants are produced.
Other known sources of hypermutability include microsatellite instability (MSI) resulting from defects in DNA mismatch repair (Timmermann et al., 2010) and elevated point mutation rates resulting from DNA polymerase defects (Di Noia and Neuberger, 2007) or AID/APOBEC1 cytidine deaminase dysregulation (Harris et al., 2002).
The fraction of unknown sequences can be particularly high in viral metagenomes because (i) viruses exhibit relatively high mutation rates resulting in distant unrecognizable homology (Bonhoeffer and Sniegowski, 2002), and (ii) this superkingdom has remained poorly explored, with relatively few sequences present in the databases.
