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But exactly how long-term exposure to low-dose radiation causes such a high mutation rate remains unknown.
Note that the estimated mutation rate remains high if mutations are nearly neutral.
TDR mutation rate remains low, but the rate of TDR-associated mutations is high.
First, consider Drake's (1991) contention that an inverse relationship exists between the mutation rate per nucleotide site and genome size in microbes, such that the genome-wide mutation rate remains constant across taxa.
Our model shows that without sensing and estimating (as it would have been in a classical mechanism of TS due to end-replication problem) the mutation rate remains unaffected and mutations can only be limited as a direct consequence of limiting the life-span of the population.
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The outcomes of simulated trials, in which half of the participants have elevated selenium levels from supplementation, depend strongly on whether the mutation rate decreases, remains relatively constant, or increases with higher selenium levels.
Our result shows that in the limit of small mutation rate, the solution remains regular in the spatial variables and yet concentrates in the trait variable and forms a Dirac mass supported at the lowest diffusion rate.
The meaning of c-MYC gain according to KRAS mutation status could not be sufficiently analysed owing to low KRAS mutation rate, and it remains to be clarified further.
That is, the number of mutation targets within a clone may increase by growth and amplification while the mutation rate per act of replication remains unchanged.
In contrast, the cause of the variation in mutation rates across autosomes remains unclear, though such variation is clearly observed between the human and chimpanzee genomes (Hodgkinson and Eyre-Walker 2011).
Thus, while choosing candidate loci with similar divergence with D. simulans accounts for mutation rate heterogeneity to some degree, there remains some residual effect of local mutation rate on locus-specific patterns of polymorphism.
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