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Exact(9)
The simulated data sets were identical to the observed data set in terms of mutation rate, recombination rate, number of sites, and number of sampled individuals.
The observed results were influenced by many genetic factors such as the mutation rate, recombination rate, gene conversion, and biased DNA mismatch repair.
A discordant result may be due to the different nature of the markers used in the different works (e.g. mutation rate, recombination, sex specific inheritance).
Population genetic simulations were used to understand the combined effect of mutation rate, recombination rate, population size, and fitness on pathway evolution.
Importantly, using real population genetic data to train our classifier will expose it to heterogeneity in mutation rate, recombination rate, and read depth.
The tempo and mode of the isochore landscape are dynamic yet influenced by several evolutionary, genetic, and population processes, including mutation rate, recombination, and population size (Eyre-Walker and Hurst 2001; Duret et al. 2006).
Similar(51)
This result holds for a wide range of mutation rates, recombination rates, and population sizes (see supplementary table S1, Additional file 1).
However, the presented approach uses realistic mutation rates, recombination rates, evolution of historical effective population sizes, and numbers of nucleotide base pairs to reflect whole genome level sequence.
Hudson's MakeSamples (ms) generates infinite-sites (Kimura 1969) genetic data under a neutral coalescent process, with specified population-scaled per-locus mutation rates, recombination rates, and migration rates.
The fact that divergence (a proxy for mutation rate) and recombination rate were negatively correlated argues against a mutagenic role of recombination.
The recombination rate calculated in the present study was five orders of magnitude higher than the estimated mutation rate, and recombination should therefore be considered as a key player in genome reshuffling through the occurrence of rearrangements.
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