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This correction in the mutation rate needed for the establishment of a quasispecies is important because estimates of genomic mutation rates of RNA viruses are usually about or below 1 [ 27, 28] (Table 6).
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In order to convert them to demographic estimates, a mutation rate needs to be assumed.
Additional uncertainty (probably larger) in the mutation rate needs to be added to these error bars.
Therefore, to obtain the demographic estimates Ne, t and m, a mutation rate needs to be assumed.
For example, in a diploid population with codominance, the population-scale mutation rate needs to be defined as Θ = 4 Ne UA, twice the value for a haploid population of the same size.
Therefore, if these markers are used to estimate CST rates given their simple and cost-effective implementation, our results suggest that their mutation rate needs to be estimated, that more than 50 markers are necessary and that allelic variability per marker should be high.
The second space develops where multiple loci are engaged in host defences, and where these defences operate at the high mutation rates needed to maintain fitness in the face of a rapidly mutating parasite environment imposing NFDS.
For a host mutation rate in Figure 2(d) of 10-3, the parasite mutation rates needed to produce the same lag loads as μ p at 10-4 in Figure 2(c) are 10-2 for sex and ~3 x 10-3 for clones, an ~10-fold reduction in μ p / μ h for sex and ~35-fold reduction of μ p / μ h in clones.
A low mutation rate was needed to sustain the di-allelism of each locus.
Further analyses of mutation rate are needed in order to resolve the effect of mutation rate on dS.
If a correlation between the two factors is to be expected, then it should be negative, as with larger population sizes a lower mutation rate is needed to maintain the equilibrium quasispecies structure.
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