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The mutation rate indicates that how many chromosomes out of the total chromosomes undergo the mutation process.
Our analysis, even by a conservative estimation of mutation rate, indicates that the SARS-CoV population has already harbored a considerable amount of genetic diversity.
The observation that most cancers do not have an abnormally high mutation rate, but the measured number of mutations is roughly equal to that expected in somatic cells having passed through many rounds of cell division acquiring mutations at the normal mutation rate, indicates that defects in instability genes are not common in the widespread non-hereditary cancers.
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The mt mutation rate was 77 times higher than the nuclear mutation rate, indicating that the phylogeny inferred from mt genes may better resolve the phylogenetic relationships among closely related Rhynchosporium species than phylogenies inferred from nuclear genes.
It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157 H7.
In this study, Watterson's estimator of mutation rate indicated that mutation may have some role in shaping the population structure of C. gloeosporioides sensu lato isolates in Trinidad and in Mexico especially with respect to the ACT and GPDH gene regions.
They are only slightly lower in adapting populations than in optimized populations evolved at the same mutation rate, indicating that adaptation takes place through an increase in the fraction of beneficial mutations, preferably of those with small effect in fitness.
Wylie and Shakhnovich (2011), for instance, have observed in a simple model that the distribution of fitness effects depends on the mutation rate, indicating that the presence of multiple mutations in the population has an effect.
Estimated times of divergence of the COI data based on a 3% Myr-1 mutation rate indicated that from an ancestral lineage of P. chilensis, HG2 and HG3 diverged ca. 470000 years ago, while HG1 diverged from HG2 260000 years ago.
Studies on the phenotypic mutation rate indicate that it is orders of magnitude larger than the genotypic mutation rate [ 11, 12]: the misreading error rate during protein synthesis is estimated to be between 10-3 to 10-4 misreadings per codon [ 13], compared with a genotypic mutation rate of between ~10-7 to 10-11 [ 14].
However, the disagreement between the most likely scenarios considering high (Ag4 and As1) and low mutation rates indicates that different processes have shaped and continue to influence the species' genetic diversity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com