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Experimental results obtained have indicated that a high mutation rate increases the success rate, although computational costs are increased too.
For phage populations with minimal genetic load, engineering mutation rate increases beyond the mutation selection balance optimum may provide even greater protection against emergent bacterial types, but only with very weak selective coefficients for de novo deleterious mutations (below ∼0.01).
Under the BDM model, the rate of speciation may increase as the mutation rate increases [ 67].
This association is predicted by models where mutation rate increases with repeat number.
4) That the mutation rate increases in correlation with compound treatment does not mean that it was causal.
It has been previously suggested that STR mutation rate increases with the number of subunits (Calabrese and Sainudiin, 2005).
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Thus, not only the mutation rate increase conferred by a mutator allele, but also its unique mutational signature (i.e., preferred type of mutation and bias to a genomic context, if any) generates its effect on genome stability and evolution.
The process is favored by the mutator phenotype of cancer cells [ 121], with the mutation rate increasing in more advanced stages [ 18].
The optimum mutation rate increased with either the fraction or the effects of beneficial mutations.
The mutation rate increased up to 25.9% for the early onset patients with other risk factor.
In model 1 (fixed mutation rate), increasing the number of housekeeper loci increased the waiting time to cancer (Fig. 6A,B).
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