Sentence examples for mutation rate increased from inspiring English sources

In general, the fraction of events called increased as the selection coefficient increased, reflecting the larger effect on the marker population caused by each mutation, and decreased as the beneficial mutation rate increased, reflecting an increased likelihood of multiple competing haplotypes within each marker.

The model where the mutation rate could vary is referred to as model 2. The switch to a mutator phenotype, whereby a cell's intrinsic mutation rate increased from μ L = 10−7 to μ H = 10−5 per-locus per division, occurred when a cell had acquired at least M mutator mutations.

Cells could also acquire mutator mutations that led to an increase in the cell's mutation rate: after M mutator mutations occurred in a single cell, the cell's intrinsic per-locus mutation rate increased from μ L to μ H mutations per division.

Based on reversion rate measurements, we also found that the mutation rate increased linearly with increasing EMS concentration (Figure 1; R2 = 0.26, F1,196 = 68.62, P<0.001, the R2 value is low due to the substantial number of populations that did not exhibit reversion).

The mutation rate increased up to 25.9% for the early onset patients with other risk factor.

The optimum mutation rate increased with either the fraction or the effects of beneficial mutations.

The process is favored by the mutator phenotype of cancer cells [ 121], with the mutation rate increasing in more advanced stages [ 18].

In model 1 (fixed mutation rate), increasing the number of housekeeper loci increased the waiting time to cancer (Fig. 6A,B).

There is a strong effect of initial repeat number, particularly for AT repeats, with mutation rate increasing with the length of the microsatellite locus in the progenitor line.

However, Rodentia and Scandentia had long branches, suggesting higher mutation rates (increased number of synonymous and non-synonymous substitutions).

Strong selection for additional driver mutations reduced the pseudo-plateau levels of genetic diversity, whilst higher mutation rates increased the pseudo-plateau level of diversity.