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Microsatellite sites diverge rapidly due to their high mutation rate; however, point mutations accumulate more slowly.
Trying to obtain too high of a mutation rate, however, is not necessarily favorable.
A low mutation rate, however, could partly explain such low diversity: rates of mitochondrial DNA evolution in elasmobranchs are slow compared to other taxa [ 16].
The high mtDNA mutation rate, however, is also the source of frequent homoplasy, i.e., phylogenetic incongruence between sites of the molecule because of multiple mutations at the same site.
We have shown that large scale differences such as leading and lagging strand synthesis and chromosomal position can influence mutation rate, however, small scale differences in the local nucleotide environment may also have an effect.
In a large population with a high mutation rate, however, multiple mutations co-occur in the population and the change in frequency of one mutation also depends on selection acting at linked sites.
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The difference in mutation rates, however, cannot explain the higher level of mitochondrial P n / P s found in birds.
For sites with increasing mutation rates, however, the probabilities for each nucleotide will decrease faster and the information content also decreases.
The mutation rate assumed, however, is a factor of uncertainty.
The mutation rate shot up, however, when Burt Richards, a scientist in Meuth's lab, accidentally allowed a dish of the tumor cells to overgrow.
In a strict neutral model of evolution, the substitution rate depends only on the mutation rate per individual; however, if there was any, even if slight, effect of selection this would not be true.
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