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Evidence that the classical trade-off observed in microbial experimental populations - that a high mutation rate facilitates rapid adaptation but at the cost of increased mutational load - can also be relevant in tumors is based on findings on chromosomal instability.
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This proposed method excels at saving decision on external parameters such as crossover and mutation rates, facilitating the improvement of computation performance.
Occasionally, increasing the mutation rate may facilitate the adaptation to different stimuli in bacterial populations [1].
In contrast, we have shown that a positive mutation rate can facilitate the establishment of a stable equilibrium.
Their intriguing idea is that sexually selected species need to evolve fast and have been selected for elevated mutation rates to facilitate this.
The mechanism itself (e.g. the weights of features) would also shed light on the exact nature of the causes of excess mutation rates and facilitate better biological understanding.
The application of a single mutation rate to all species facilitates the direct comparison of skyline diagrams and the relative timings of expansion events.
In addition, special features of the GA were included to dynamically alter the population size, and the crossover and mutation rate in order to facilitate faster convergence and hence reduce the computational effort required.
Once cancerous traits have evolved, an elevated mutation rate and metastatic potential may facilitate diversification and persistence of the cancerous cells (Bielas et al. 2006).
Only phages that are endowed with disposable side tail fibers and facilitated by high mutation rate can quickly adapt to both the planktonic liquid culture and the benthic biofilm habitats.
Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.
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