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Whether the realized cost of msh2Δ in our sexual populations was direct or indirect, our results have some implications for both theoretical studies of mutator dynamics and the understanding of mutation rate evolution in natural populations.
The notion that recombination is perhaps not the only factor that can prevent mutator hitchhiking in sexual populations has implications for mutation rate evolution in natural populations that can reproduce sexually but go through a prominent haploid phase: for example, fungi, algae and some plants.
Most studies of mutation rate evolution have adopted the simplifying assumption that mutator alleles are themselves neutral in the short term.
In addition, the level of recombination is also critical for mutation rate evolution (see Box 2).
Nevertheless, the preceding results help clarify two key issues with respect to the constraints on mutation rate evolution.
Here, it is suggested that the lower barrier to mutation rate evolution may ultimately be defined not by molecular limitations but by the power of random genetic drift.
Similar(50)
At moderate mutation rates evolution leads to longer genomes with a higher diversity than at high mutation rates.
The tinkering effect of selection on mutation rate expedites evolution and the jackprot model shows it.
Giraud, A. et al. Costs and benefits of high mutation rates: Adaptive evolution of bacteria in the mouse gut.
In these systems, high mutation rates make evolution happen in front of our eyes.
Lowering the mutation rate caused the evolution of parasites, which, however, enabled the evolution of even greater diversity.
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