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The slowest mutation rate estimate would inflate these time estimates by one-third, and the fastest would deflate them by 17%.
In addition, the mutation rate estimate from chronic infection likely represents an overestimation because of functional inactivation of mutation repair genes mutY and uvrC by frameshift mutations in the strain with the highest mutation rate (Supplementary Table 6).
To determine the sensitivity of inferred population dynamics to mutation rate, two additional BSPs were constructed using the 25th and 75th percentile of the highest posterior density (HPD) interval corresponding to the mean mutation rate estimate.
That would have given a mutation rate estimate of 16/2362.5 = 0.006772, or a reduction in mutation rate estimate by 35%.
Fourth, he included Vireo olivaceus although the mutation rate estimate was based on one single offspring!
With this mutation rate estimate, we arrive at s ^ ≈ 0.07 per generation.
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This is the first analysis of mutational processes and mutation rate estimates in the nuclear genome of P. pacificus because previous knowledge is based solely on the mitochondrial genome (Molnar et al. 2011).
We used mutation rate estimates for specific mutational events to judge relative probabilities of different scenarios.
However, there is an increasing discrepancy between the overall mutation rate estimated from likelihood analysis and that from the classical estimator when the rate is significantly higher than 1%.
Thus 'hidden' mutational bands in extra-pair offspring will cause a bias in mutation rate estimates, and, therefore, they have to be excluded.
fg=3.9 A gene-specific background mutation rate estimated by MutSigCV.
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