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Supportive evidence can be collected for instance via the study of mutation rates: communities dependent on cooperation in an open environment should have a smaller number of mutants as compared to the same community in a well-mixed (i.e. globally communicating) environment.
Significantly mutated genes (SMGs) were defined as the somatic mutations with higher mutated frequency than background mutation rate.
In the study by Barua et al. [ 25], the new mutation rate determined following parental ultrasound examination was ~10%, suggesting that in more than a fifth of our patients, a diagnosis of ADPKD is not being communicated or is undiagnosed.
Mutation rate: mutations per cell per generation.
Lynch, M. Evolution of the mutation rate.
(b) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).
The mutation rate was set to 2 × 10−8.
Genomic factors that affect mutation rate in non-coding elements.
fg=3.9 A gene-specific background mutation rate estimated by MutSigCV.
We used a grass-specific mutation rate of 1 × 10−8.
(c) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).
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