The influenza A virus has a high mutation rate and thus a large number of strains.
We used this mutation rate and the calculator because of the evidence of nonlinearity in human mtDNA mutation rate, and the necessity for correction of time estimates for purifying selection91,92.
All G-PhoCS parameters are scaled by mutation rate and simulations are not dependent on the true value.
Tomlinson, I. & Bodmer, W. Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog.
This will allow us to learn about the determinants of mutation rate and the mechanisms impacting its evolution across species.
Promising candidates should be in use within 15 years but will require continuous modification to keep pace with the virus's prodigious mutation rate and recombination of strains.
The dependence of Tc on the mutation rate and on the fitness landscape is also studied.
In addition to recombination and population history, mutation rate and process are expected to shape LD.
However, little is known about the mutation rate and genomic changes induced by the inflammatory response during the initial, acute bacterial infection.
For example, researchers are now finding that non-steroidal inflammatory drugs can slow down the mutation rate and reduce the progression of esophageal cancer.
Here we show that this result holds in fact for a wide class of stochastic birth death processes for arbitrary mutation rate and for any intensity of selection.
