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Mutation rate also influences genetic variability.
The mutation rate also determines the spread of the population in sequence and structure spaces.
A few studies have demonstrated that the mutation rate also can affect SNP density.
The overall average mutation rate also depends on the distribution of repeat numbers per motif in the genome.
The nature of the dominating factors that shape the optimum mutation rate also needs to be determined.
Hypomethylated Dnmt1−/− mESCs, which had the highest de novo mutation rate, also displayed the widest variety of mutation types, indicating that several different mutational processes may occur in this cell line.
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Inspection of the empirical distribution of scaled mutation rates also suggests ample variation in per nucleotide mutation rate throughout the genome.
This greater than 20-fold difference in mutation rates also illustrates why protein-based phylogenies are better for reconstructing distant relationships than DNA-based ones.
The results reported here suggest that high mutation rates also allow clades to speciate more rapidly, diversifying into new niches (potentially as new niches arise).
For example, if species with higher mutation rates also have larger populations, then the increased efficacy of purifying selection could lead to a reduction in the rate of substitution due to genetic drift.
Under these interpretations, our data would suggest that genes experiencing high mutations rates also face greater purifying selection.
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