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This mutation raises an important question – how much ACE (tissue and/or blood) is appropriate to maintain healthy conditions?
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These mutations raise a woman's risk for breast and ovarian cancer, as well as a man's risk of prostate cancer, because they disable proteins that repair DNA damage that can result in additional cancer-spurring mutations.
Myriad executives have said that when a European laboratory finds a mutation in either of the two genes, 20 to 40 percent of the time it does not know if the mutation raises the cancer risk.
The finding of virus expression and mutation raises questions as to whether or not these activities are related to ATLL relapse or progression.
The mutation raises the net charge of the 100-residue N-terminal domain from +4 to +6.
It is likely that the Y254V mutation raises the free energy barrier of the transition state by disrupting coordination along the pathway of the translocation step.
The frequency of this mutation raises the possibility that variants with this alteration could be involved in the development of high grade intraepithelial and invasive disease.
The advent of highly sensitive methods for mutation detection raises a provocative question whether any mutation detected should preclude the use of cells in various in vitro applications and particularly in potential therapies.
Moreover, the second RASCAL trial reported a poor outcome only for a small subset of patients bearing a G12V mutation raising the question on the possible prognostic relevance of specific KRAS mutations (Andreyev et al, 2001).
In Bacillus sp. G1 a H47T mutation raised the ratio of γ-CD formed (Table 2), though the total γ-CD yield was only mildly enhanced.
Insertion of a point mutation within the AfFKS1 gene to generate a S678Y amino acid substitution resulted in an MEC of 4 μg/ml (Gardiner et al., 2005) and introducing a S678P mutation raised the MEC of caspofungin, anidulafungin and micafungin to >16 μg/ml (Rocha et al., 2007), compared to 0.25 μg/ml with the susceptible wild-type strain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com