Sentence examples for mutation proportion was from inspiring English sources

Thus, indels were only called if the false mutation proportion was less than 2.15 × 10−2.

In order to prevent outlier libraries from influencing the background reading, false mutation proportions were estimated by calculating the median rate of occurrence of each mutation type across all samples for each nucleotide position.

In this setting, the phenomenon of genetic heteroplasmy arises, where a proportion of genomes contain a mutation, and a proportion are wild-type (normal).

In breast malignancies from patients with a BRCA1 mutation, a greater proportion are high grade and histologically medullary or atypical medullary in type [ 14, 15*].

Up to 25% of the PCR-direct sequencing negative cases turned out to be positive in SPACE-HRM mutation tests, and this proportion is 20% by the Scorpion-ARMS.

Second, in large populations, a higher proportion of mutations are expected to be effectively selected because a higher proportion are expected to have N e s ≫ 1.

Indels occurring at sites with a false mutation proportion greater than this were not included in the analysis.

However, these false mutation calls are consistent across samples (Additional file 1: Figure S1) and thus the false mutation proportion of each mutation type can be estimated individually at each nucleotide position.

Table 3 shows that the proportion of mutation carriers was generally greater if the proband had a family history of ovarian cancer, irrespective of whether it was in a first-degree or a second-degree relative.

For unaffected probands, Table 1 shows that the proportion of mutation carriers was 12% in those under 40 years compared with 6% in those 40 years or older (P = 0.25).

The average between the true mutation proportions of each technical replicate was used to provide a rough estimation of the total number of each type of mutation.