Sentence examples for mutation proportion for from inspiring English sources

Due to homopolymer sequencing errors, the false mutation proportion for some insertions/deletions (indels) can be much higher than false mutation proportions for base substitutions.

For each mutation detected, we divided the true mutation proportion by the expected mutation proportion for a single mutation (threshold) to estimate the number of copies of that mutation in any given sample.

The data were then normalized by subtracting the false mutation proportion from the total mutation proportion to determine the true mutation proportion at each nucleotide position (Additional file 1: Figure S2; see glossary for clarification).

Thus, the false mutation proportion subtraction accounted for many sequencing artefacts occurring around homopolymer regions.

After correcting for the false mutation proportion, we explored mutation calling using three different thresholds for optimization (Additional file 1: Table S1).

At each nucleotide position, a proportion of reads is expected to carry a technical artefact (e.g., PCR artefacts and sequencing noise) for each possible mutation type (referred to as the false mutation proportion: see glossary in Table  1).

Then, for each BAR mutation, the proportions for the different integrations were pooled.

The thresholds were set at: 1) the exact proportion for the mutation expected; 2) 75%% of the expected proportion; and 3) 50%% of the expected proportion.

However, for noncoding AT mutations, the proportion of singletons is higher than that of noncoding GC mutations (35.2% vs. 32.8%).

The mutation accounted for a significant proportion of the phenotypic variance in muscle score and calving difficulty.

Optimal circumstances are present, when a single disease-causing mutation accounts for a large proportion of the phenotypic variance and has arisen recently on a relatively uncommon haplotype background [ 128].