The standard heat maps are ideal for situations where a specific mutation-unfolding propensity is desired, for example, a clinical setting.
Our experiments with TOG domains indirectly probed the conformation of terminal subunits and showed that the β T238A mutation reduces the propensity of terminal αβ-tubulins to be curved.
Moreover, mutations in Aβ sequence, such as the Dutch and Iowa mutations, increase Aβ propensity to aggregate specifically on microvessels and decrease its cerebral clearance in patients with familial CAA.
And most mutations suggest a propensity, not a guarantee, for a disease.
Our results suggest a role for KRAS mutations in the propensity of primary colorectal tumors to metastasize to the lung.
The Flemish and Arctic APP mutations increase the propensity for fibrillization and decrease proteolytic clearance of Aβ peptides [17], [18], [19], [20].
CADASIL-associated mutations confer NOTCH3ECD propensity to self-aggregate, sequestering wild-type NOTCH3 and other extracellular molecules (Duering et al, 2011).
Since 1998, circulating influenza viruses in pigs have been able to change because of mutations and the propensity for influenza A virus of swine with the triple reassortant genotype to frequently reassort and generate new genotypes, therefore increasing the diversity of influenza A virus in swine (14 ).
While mass vaccination of a susceptible population is the best approach to prevent influenza infections, propensity for mutation and gene reassortment can result in an occasional emergence of novel and unpredicted influenza virus strains.
All of these Aβ variants, except the Flemish mutation, have a greater propensity to aggregate into protofibrils and/or fibrils than wild-type Aβ [31], [34], [35], [36], [37], and have been reported to be more toxic to neuroblastoma cells in vitro [38], [39], [40], [41], [42].
Nucleosome arrays carrying K16ac and R23C, but not control variants with only the R23C mutation, displayed drastically reduced propensity to compact and self-assemble.
