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Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), and mutation profiles of 1,542 RBPs in ∼7,000 clinical specimens across 15 cancer types.
Mutation profiles of the transgenic and wild-type genomes were examined by next-generation sequencing (NGS).
Mutation profiles of viral genomes were complicated in ALD patients and HBeAg negative patients.
Mutation profiles of 32 mutant samples with 41 mutations were repeated with the ColoCarta.
The mutation profiles of the sequenced isolates are listed in Table 4.
We use somatic mutations to generate the mutation profiles of cancer patients.
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The first comprehensive mutation profiling of 623 genes in 188 adenocarcinomas identified 26 significantly mutated genes, including known oncogenes (KRAS, EGFR, ERBB2, ERBB4, EPHA3 and other ephrin receptor genes, KDR, and FGFR4) and tumor suppressor genes (TP53, CDKN2A, STK11, NF1, ATM, RB1, and APC) [ 7].
The mutation profile of the viruses infecting these individuals were deduced and correlated to laboratorial parameters.
Kanagal-Shamanna, R. et al. Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics.
Thus, we report a high-throughput, multiplexed strategy for single-cell mutation profiling of individual lung cancer CTCs toward minimally invasive cancer therapy prediction and disease monitoring.
This suggests that the association may involve an interaction with another factor that is unique to early-onset patients such as the expression or somatic mutation profile of the tumour.
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