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Constitutive activation of c-KIT, associated with various mutation profiles, is observed in the majority of GISTs.
If it is assumed that the TEM β-lactamase encoded by such a construct is functional, the analysis of novel mutation profiles is valuable data, though, to study sequence-function relationships and to predict mutations which might also occur in microbial TEM β-lactamases in the future.
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If the mutation profiles were identical, the protein was named accordingly (e.g. "SHV-3").
Also, three assigned mutation profiles were identified to be in doubt: SHV-16, SHV-103, and SHV-104.
Comprehensive mutation profiles are generated for individual tumors through amplification of transposon insertion sites followed by high-throughput sequencing.
Similarly, point mutation profiles are transformed from columns in multiple alignments computed for gene families with elements present in at least | S | - 1 strains.
Mutation profiles were compared with that of genomic DNA extracted from 3 to 5 million cells harvested from the same culture flask.
Similar mutation profiles were shown in samples collected in Beijing (136) and in a relatively isolated town 600 km south from Beijing (21).
This suggests that this mutation profile is the result of an endogenous mutational process for example, a defect in DNA repair that was acquired before the divergence of the two lineages, or that it was caused by independent exposure of the two lineages to a carcinogenic environmental agent.
The mutation profile is represented as a vector: v : S → ∑ ∪.
A typical comparison between the reconstructed and observed mutation profile is given in Figure S2B.
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