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The 12 NCBI peptide database entries with inconsistencies include wrongly named sequences (IRT-18 and TEM-77, GI 6688989) and sequences for which the mutation profiles do not correspond to those listed in the TEM mutation table.
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Doebele et al. [ 10] have shown that the mutation profile (EGFR/KRAS/ALK) did impact the metastatic spread pattern and one can hypothesize that wild-type EGFR clones have enhanced brain metastatic potential and that patients with EGFR-mutated tumors may develop fewer BM than patients with wild-type EGFR tumors.
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Analogously, we call a mutation profile complete if it does not contain question marks.
Most of the novel mutation profiles originate from artificial constructs such as cloning vectors, and hence do not qualify for the assignment of a new TEM number.
0 if v(s) = v(r) 1 otherwise Analogous to mutation profiles, we call a binary mutation profile complete if it does not contain question marks.
In addition, while mutation of the terminal phenylalanine reduced growth, the phenotypic profile did not resemble tra1- L3733A.
Favero, F. et al. Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data.
In the next step, GWAMAR computes binary mutation profiles for each mutation profile.
Next, GO-based mutation profiles (GO-MP) are obtained by multiplying the mutation profile matrix by the gene profile matrix.
A dog's profile does what?
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