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This suggests that this mutation profile is the result of an endogenous mutational process for example, a defect in DNA repair that was acquired before the divergence of the two lineages, or that it was caused by independent exposure of the two lineages to a carcinogenic environmental agent.
The mutation profile is represented as a vector: v : S → ∑ ∪.
A typical comparison between the reconstructed and observed mutation profile is given in Figure S2B.
In the SHVED, the wrong name assignment is corrected if its mutation profile is already included in SHV mutation table.
Then, for a given mutation profile v its corresponding binary mutation profile is defined as follows: b (s ) = ?
The wrong name assignment is corrected in the LacED if the mutation profile is included in TEM mutation table.
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On the other hand, the K-ras mutation profile was not related to the level of 8-OH-dG.
Otherwise it was named "SHV-like" and its mutation profile was stored.
Otherwise, a new protein entry was created and its mutation profile was stored.
The main characteristics of the proposed patient mutation profile are as follows: Compact.
By systematic analysis of protein sequences in the SHVED, 41 protein sequences with a new mutation profile were identified.
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