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The mutation profile found in the primary tumour was found in all of the cervical smears [ 25].
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In addition to the full length sequences, 6 fragments from microbial source with a new mutation profile were found.
We did not find any correlation between the gene mutation profile and NTM infection.
The presence of these core promoter mutations are also related to the above-mentioned HBeAg-antiHBe concurrent profile found in this patient, as recently reported [ 23].
Half of the 180 TEM β-lactamases with a new mutation profile which have been found in the NCBI peptide database but not described yet in the TEM mutation table were of microbial origin.
One TP53 mutation (p.R248Q; c.743G>A) was found in a gcGBM tumor sample but additional mutations profiled by the SNaPshot system were absent in these gcGBM cases.
Here we provide a computational pipeline to find the minimal set of epitopes based on patient haplotypes and patient specific mutation profile that help in simulating cytotoxic T cell mediated immunity.
We found that C→T and C→A were the predominant types of postzygotic mutations, similar to the somatic mutation profile in tumor tissues.
In 82 protein sequences found only in the NCBI protein database, there are 41 sequences which originate from microbial sources and harbor a new mutation profile.
In the next step, GWAMAR computes binary mutation profiles for each mutation profile.
Next, GO-based mutation profiles (GO-MP) are obtained by multiplying the mutation profile matrix by the gene profile matrix.
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