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However, part of the mutation produced by transposable elements might affect genes useless in laboratory conditions and will therefore be taken into account in the calculation of mean fitness effects of mutations even if they do not affect any phenotype in the laboratory environment.
The final clinical outcome (e.g. cancer) does not depend on the first DNA adduct formed or a genetic mutation produced by xenobiotics.
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However, only limited data are available on the specific mutations produced by SM.
This can be seen by considering the mean number of mutations produced by the resistant cell population by time t, that is, approximately.
Mutations produced by the integration of the Himar1 transposon into the A. marginale chromosome will generate new junction sequences that are absent in the wild-type.
Mutations produced by error-prone repair processes, although not targeted to specific genes, are not randomly scattered in the genome either.
Analysis of the types of mutations produced by mutagenic agents can provide insight into the mechanism of mutation and can suggest which DNA lesions may be involved in the actual mutagenic event.
Notably, all of the amino acid mutations produced by the missense mutations are predicted to be mutagenic, using the SIFT tool, which sorts intolerant from tolerant substitutions on the basis of conservation of the particular amino acid in related proteins (Ng and Henikoff 2001).
The functional impact scores that measure the deleteriousness of laboratory-induced mutations produced by Condel were quite similar for lab-damaging mutations that completely abolished protein function and the remainder of lab-damaging mutations that exhibited partial protein function (Fig. 3B).
Genetic variation produced by mutation and recombination has probabilistic (chance) elements the opposite of what the public thinks of chance.
About equivalent mutants: one of the objectives of the study is to verify if a given mutation produced is detected by FindBugs Tool, and this is done statically, without the necessity of the mutant execution.
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