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Similar plots demonstrating prediction power for successive sampling sites were constructed using estimated mutation prevalences from a sequencing study by Gerlinger et al. [ 26].
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Recent studies have described a gradual increase in CIMP and BRAF mutation prevalence from the rectum to the ascending colon [ 12, 13].
In conclusion, the extensive mutation frequency data summarized in this paper provides a useful context in which mutation prevalence data from population-based surveillance studies of transmitted resistance can be interpreted.
Myriad elaborated mutation prevalence tables from the analysis of 3410 individuals.
This trend in mutation prevalence with time from initial gene discovery is typical for many heritable syndromes as more probands without family histories and without full phenotype are analyzed, thus making molecular diagnosis difficult and predictive testing challenging, often impossible.
There was evidence of increasing mutation prevalence at increasing distance from the transcription start site, suggesting that the suppressive influences of transcription upon mutagenesis described above wane as proximity to the TSS decreases.
Finally, we examined the relationship between distance from the transcriptional start site (TSS) and mutation prevalence in protein coding genes.
Cancers showed variation in mutation prevalence, with many of the cancer types with highest prevalence originating from high turnover, surface epithelia that are most exposed to mutagens [12].
The overall mutation prevalence was 7% in North Sardinia and 17% and 18% in families from Middle and South Sardinia, respectively.
In this study, the relationship between lesion growth and mutation prevalence within a lesion was investigated.
To evaluate the mutation prevalence and phenotype in genes involved in the ocular retinoid metabolism.
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