Sentence examples for mutation prevalences from inspiring English sources

Race is an important predictor of breast cancer risk [ 36], and hereditary patterns and mutation prevalences differ by race and ethnicity [ 37].

Similar plots demonstrating prediction power for successive sampling sites were constructed using estimated mutation prevalences from a sequencing study by Gerlinger et al. [ 26].

As shown in Figure 5B, the estimated mutation prevalences for BAP1, SETD2, and PBRM1 mutations were 41%, 53%, and 69%, respectively, compared to our cohort which was 58%, 70%, and 75%, respectively.

Slight discrepancies between our observations and the reported mutation frequencies for oncogenes included lower than expected mutation prevalences for beta-catenin (CTNNB1) and BRAF in pancreatic and colorectal tumours, respectively; and higher than the reported frequencies for NRAS in colorectal cancer.

Higher KRAS2 mutation prevalences have been reported in pancreatic or duodenal juice (63 to 87%), due probably to higher DNA tumour content in pancreatic juice as compared to plasma (Wilentz et al, 1998; van Laethem et al, 1998; Watanabe et al, 1999).

PIK3CA contains a total of five domains, so we compared the domain peaks identified by our method to the domains identified with high mutation prevalence, a measure commonly applied to identify genes mutated in a high percentage of patients.

Particularly, one SMG (ie, FAT4) exhibited mutation prevalence of >10% and two SMGs (ie, DOCK2, CDH10) mutated at frequencies of >7%.

For example, determining mutation prevalence (for a range of specific mutations, as well as mutational frequency of any single gene), or the frequency at which any particular gene leads to any single phenotype, remains to be defined for most diseases.

The results indicate that mutational processes characterized by both transcriptional strand bias and expression-related mutation prevalence are operative in breast cancer, similar to our previous observations in melanoma and lung cancer.

Three novel recurrently mutated genes, namely CDH10, FAT4 and DOCK2, were identified to exhibit high mutation prevalence in the Asian CRC cohort.

In this study, the relationship between lesion growth and mutation prevalence within a lesion was investigated.