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Among women in our study who were diagnosed before the age of 35, the mutation prevalence was 8.3%.
The overall mutation prevalence was 7% in North Sardinia and 17% and 18% in families from Middle and South Sardinia, respectively.
All five BRCA1 mutations were seen in white women between the ages of 31 and 40; in this subgroup the mutation prevalence was 17%.
Mutation prevalence was substantially higher in cases diagnosed before 35 years-of-age and with increasing number of relatives affected with breast or ovarian cancer.
Among 46,276 subjects (78.3 % Western European ancestry and 3.8 % African ancestry) tested by Myriad Genetics, Inc., BRCA1 and BRCA2 mutation prevalence was 10.2 and 5.7 % in the African ancestry group, respectively versus 6.9 and 5.2 % in populations of Western European ancestry [ 31].
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The results indicate that mutational processes characterized by both transcriptional strand bias and expression-related mutation prevalence are operative in breast cancer, similar to our previous observations in melanoma and lung cancer.
Overall these studies suggest that 816 c-kit mutation prevalence is high in adult patients and low in pediatrics patients.
Overall, the mutation prevalence is relatively low 20-300%).
This is a result of mutation prevalence being estimated to be 2.5% in their model.
Among Eastern Asian patients with NSCLC, K-Ras mutation prevalence is generally less than 10% and is very rare among squamous cell carcinoma and never-smoker patients [26].
Among Caucasians, the average EGFR mutation prevalence is approximately 7% overall, 13% among patients with adenocarcinoma, and 35% among never-smokers [20].
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CEO of Professional Science Editing for Scientists @ prosciediting.com