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On the contrary, when the mutation pressure favors AT, most of the mutations that are eliminated yield proteins that are unstable against misfolding.
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While one would predict, under the CA hypothesis, that both of these sets of genes (mito-annotated and core mito-proteome) would evolve to be enriched on the X-chromosome, the data from mito-annotated genes across mammals suggest otherwise, and implies that male-harming mitochondrial mutation pressure has favored their movement off-the-X [ 18].
Loss of efficiency of one or more DNA repair mechanisms, whether by germline inheritance or sporadic mutation, accelerates the rate of accumulation of additional mutations by 100 1,000 times, with selective pressure favoring those mutations that drive carcinogenesis – the "mutator phenotype".
Highly expressed genes typically exhibit higher bias in synonymous codon usage, and it has been proposed that mutation pressure and natural selection are the major forces influencing this phenomenon, favoring translationally superior codons [ 23- 27].
High pressure favors the formation of acetic acid.
Positive selection pressure favors nonsynonymous substitutions particularly in the ABS.
Theoretical studies suggest that, under stressful conditions, selective pressure favors hypermutator strains over nonmutator strains [40] [42].
Evolutionary pressure favors the energy efficient processing of information.
Perhaps selective pressure favors different MAOA alleles in varying macaque populations or environments.
The literature shows that selective pressure favors transmission and spread of MRSA in pigs (13, 21 ).
The dN/dS ratio was significantly elevated at this position only in Mamu-B*08-positive animals, indicating strong selection pressure favoring this mutation only in the presence of Mamu-B*08 (data not shown).
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